Description

Gw4869 CAS NO 6823-69-4 is a high-purity, small-molecule chemical compound widely utilized in advanced life science research and development. This product is valued for its critical role as a potent and selective inhibitor of neutral sphingomyelinase (nSMase), a key enzyme in sphingolipid metabolism. It is an essential research tool for scientists and pharmaceutical developers investigating cellular signaling pathways, neurodegenerative diseases, and exosome biology. Our supply ensures consistent quality and reliable availability for global R&D and pilot-scale production needs.

Application

• Biomedical Research: Used as a selective nSMase inhibitor to study ceramide-mediated signaling pathways, apoptosis, and stress responses in cell culture models.
• Neurodegenerative Disease Studies: A key research compound for investigating the role of sphingolipid metabolism in conditions such as Alzheimer's disease, Parkinson's disease, and multiple sclerosis.
• Exosome & Vesicle Biology: Employed to inhibit exosome secretion and biogenesis, making it crucial for studying cell-cell communication, tumor microenvironments, and diagnostic biomarker discovery.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in preclinical drug discovery programs targeting nSMase for therapeutic intervention.
• Academic & Institutional Research: Supplied to universities and research institutes for fundamental studies in biochemistry, cell biology, and molecular pharmacology.

Basic Information

Product Name	Gw4869 CAS NO 6823-69-4
CAS No.	6823-69-4
Molecular Formula	C₁₇H₁₄N₂O₃
Molecular Weight	294.31 g/mol
Synonyms	GW4869; GW-4869; 2,2'-[Hexamethylenebis[(3,4,5-trimethoxybenzoyl)oxy]]bis[1-methylpyridinium] dichloride; 1-Methyl-2-[(3,4,5-trimethoxybenzoyl)oxy]-3-[[6-[[(3,4,5-trimethoxybenzoyl)oxy]-1-methylpyridinium-2-yl]oxy]hexyl]pyridinium dichloride; Neutral Sphingomyelinase Inhibitor; nSMase Inhibitor
EINECS	Contact for details

Quality Control

Our Gw4869 is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for research chemicals, and our quality protocols are designed to meet the stringent requirements of pharmaceutical and academic research.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The product is light-sensitive and should be handled and stored away from direct light exposure to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.