Description

Tyramine-7-14C Hydrochloride is a carbon-14 labeled isotopologue of tyramine hydrochloride, a key biogenic amine and trace amine-associated receptor (TAAR) agonist. This radiolabeled compound is essential for conducting precise metabolic, pharmacokinetic, and receptor binding studies, providing critical data on the fate and distribution of tyramine in biological systems. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic researchers in neuroscience and drug discovery.

Application

• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used as a radiotracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profile of tyramine and related compounds.
• Neuropharmacology Research: Critical for in vitro and in vivo studies targeting trace amine-associated receptors (TAARs), particularly TAAR1, to understand their role in neurological and psychiatric disorders.
• Biochemical Pathway Tracing: Enables the elucidation of tyramine's metabolic pathways, including its conversion to octopamine, in both mammalian and insect systems.
• Analytical Method Development: Serves as an internal standard for the development and validation of highly sensitive LC-MS/MS or radio-HPLC methods for quantifying tyramine in complex matrices.
• Preclinical Safety Assessment: Employed in toxicology studies to identify potential metabolite-related toxicity and understand tissue-specific accumulation.

Basic Information

Product Name	Tyramine-7-14C Hydrochloride
CAS No.	6793-91-5
Molecular Formula	C8H11NO • HCl (with 14C at position 7)
Molecular Weight	~187.64 (unlabeled) *Contact for exact specific activity and labeled MW.
Synonyms	4-(2-Aminoethyl)phenol-7-14C Hydrochloride; 2-(4-Hydroxyphenyl)ethylamine-7-14C Hydrochloride; p-Hydroxyphenethylamine-7-14C Hydrochloride; p-Tyramine-7-14C Hydrochloride; [7-14C]Tyramine Hydrochloride; 4-Hydroxy-β-phenylethylamine-7-14C Hydrochloride; TOAM-7-14C Hydrochloride
EINECS	Contact for details

Quality Control

Every batch of Tyramine-7-14C Hydrochloride is manufactured and analyzed under strict quality control protocols to ensure identity, purity, and specific activity. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request and provide detailed data on radiochemical purity, chemical purity, specific activity, and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storage at or below -20°C under desiccant. Follow all applicable laboratory safety and radiation protection guidelines.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR / NMR)	Conforms to structure
Assay (HPLC)	≥ 98% (Chemical Purity)
Radiochemical Purity (Radio-HPLC)	≥ 97%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.