Description

(2S,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid is a high-purity, non-proteinogenic amino acid derivative featuring a fluorinated pyrrolidine backbone, which is critical for modulating the physicochemical and metabolic properties of bioactive compounds. This chiral building block is essential for medicinal chemistry research and development, particularly in the design of peptide mimetics and enzyme inhibitors. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers focused on creating novel therapeutics, including protease inhibitors and drug candidates targeting the central nervous system.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs), especially for protease inhibitors.
• Peptidomimetic Design: Used to introduce conformational constraints and enhance metabolic stability in peptide-based drug candidates.
• Medicinal Chemistry Research: Serves as a versatile building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Biochemical Probe Development: Employed in the creation of fluorinated analogs to study enzyme mechanisms and binding interactions.
• Fine Chemical Synthesis: A valuable intermediate for custom synthesis and contract manufacturing of complex organic molecules.

Basic Information

Product Name	(2S,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid
CAS No.	6745-32-0
Molecular Formula	C5H8FNO2
Molecular Weight	133.12 g/mol
Synonyms	(2S,4S)-4-Fluoroproline; (4S)-4-Fluoro-L-proline; 4-Fluoro-L-proline; L-4-Fluoroproline; (2S,4S)-4-Fluoropyrrolidine-2-carboxylic acid; 4-Fluoro-(S)-proline; 4-Fluoro-L-2-pyrrolidinecarboxylic acid; 6745-32-0
EINECS	Contact for details

Quality Control

Our (2S,4S)-4-Fluoropyrrolidine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.