Description

Zebularine is a potent and stable cytidine analog that functions as a DNA methyltransferase (DNMT) inhibitor. This mechanism is critical for epigenetic research and therapeutic development, as it allows for the reactivation of silenced tumor suppressor genes. It is an essential biochemical tool for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on oncology, neurology, and epigenetics. Zebularine CAS NO 6710-48-1 offers a reliable reference standard and active ingredient for high-value applications.

Application

• Epigenetic Research & Drug Discovery: As a DNA demethylating agent for studying gene expression regulation and developing novel cancer therapeutics.
• Oncology Studies: Investigation of tumor suppressor gene reactivation and combination therapies in various cancer cell lines.
• Biochemical Reference Standard: Used for method development, validation, and quality control in analytical laboratories.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of more complex nucleoside-based active pharmaceutical ingredients (APIs).
• Cell Biology & Differentiation: Tool for probing the role of DNA methylation in stem cell differentiation and cellular reprogramming.
• Neurological Research: Exploring the epigenetic basis of neurological disorders and potential treatment pathways.

Basic Information

Product Name	Zebularine
CAS No.	6710-48-1
Molecular Formula	C9H12N2O5
Molecular Weight	228.20 g/mol
Synonyms	1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one; 1-(β-D-Ribofuranosyl)dihydropyrimidin-2-one; 1-(β-D-Ribofuranosyl)-1,2-dihydro-2-pyrimidinone; 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one; NSC 309132; 1-(β-D-Ribofuranosyl)-2(1H)-pyrimidinone
EINECS	Contact for details

Quality Control

Our Zebularine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a comprehensive Certificate of Analysis (COA). We support compliance with relevant research and development standards, and specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a desiccated environment. For long-term storage, consider under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.