Description

4-Fluoro-3-Nitrobenzenesulfonyl Chloride is a versatile and reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its value lies in its ability to introduce the sulfonamide functional group, a key moiety in the development of active pharmaceutical ingredients and specialty agrochemicals. This high-purity intermediate is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to create novel compounds with targeted properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and insecticides that require the sulfonamide pharmacophore.
• Dyestuff and Pigment Manufacturing: Used in the production of specialty dyes and colorants where the sulfonyl chloride group enables chromophore attachment.
• Polymer Modification: Functional monomer for creating specialty polymers with specific surface properties or reactivity.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry for constructing complex molecular architectures.
• Ligand and Catalyst Preparation: Intermediate for synthesizing specialized ligands used in catalytic systems and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Fluoro-3-Nitrobenzenesulfonyl Chloride
CAS No.	6668-56-0
Molecular Formula	C6H3ClFNO4S
Molecular Weight	239.61 g/mol
Synonyms	3-Nitro-4-fluorobenzenesulfonyl chloride; 4-Fluoro-3-nitrobenzene-1-sulfonyl chloride; 1-Fluoro-2-nitro-4-(chlorosulfonyl)benzene; 4-Fluoro-3-nitrobenzenesulphonyl chloride; NSC 403796; Benzenesulfonyl chloride, 4-fluoro-3-nitro-; p-Fluoro-m-nitrobenzenesulfonyl chloride
EINECS	229-709-4

Quality Control

Every batch of our 4-Fluoro-3-Nitrobenzenesulfonyl Chloride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high standards required for research and commercial synthesis. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Off-white to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.