Description

Alosetron is a potent and selective 5-HT3 receptor antagonist used in pharmaceutical research and development. This compound is of significant interest for its targeted mechanism of action, which modulates serotonin pathways in the gastrointestinal tract. It is primarily utilized by pharmaceutical companies, contract research organizations (CROs), and academic institutions engaged in the development of treatments for functional gastrointestinal disorders.

Application

• Pharmaceutical Active Ingredient (API): Serves as the key therapeutic agent in the formulation of prescription medications.
• Reference Standard: Used as a high-purity standard in analytical laboratories for quality control, method development, and validation of assays.
• Biomedical Research: A critical tool for in vitro and in vivo studies investigating the role of 5-HT3 receptors in visceral pain, motility, and secretion.
• Drug Discovery & Development: Employed in preclinical research for screening, pharmacology studies, and as a lead compound for developing new chemical entities.
• Metabolite Synthesis: Used as a starting material or intermediate in the synthesis of metabolites for pharmacokinetic and toxicological studies.

Basic Information

Product Name	Alosetron
CAS No.	122852-42-0
Molecular Formula	C17H18N4O
Molecular Weight	294.35 g/mol
Synonyms	Alosetron Hydrochloride; GR 68755; GR-68755C; Lotronex; 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one; (5-Methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one)
EINECS	Contact for details

Quality Control

Our Alosetron is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC, to ensure it meets stringent pharmaceutical-grade specifications. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.