Description

2,4,6-Triisopropylbenzenesulfonyl Chloride is a specialized organosulfur reagent widely used as a versatile sulfonylation and activating agent in organic synthesis. Its sterically hindered triisopropylphenyl group makes it particularly valuable for creating robust protecting groups and facilitating challenging coupling reactions. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable and selective reagents for complex molecular construction.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for the preparation of sulfonamides, sulfonate esters, and as an activating group in peptide and nucleoside chemistry.
• Agrochemical Production: Used in the synthesis of novel herbicides, fungicides, and insecticides that require sulfonyl-based active ingredients.
• Polymer & Material Science: Serves as a functionalization agent or cross-linking precursor in the development of specialty polymers and advanced materials.
• Protecting Group Chemistry: The 2,4,6-triisopropylbenzenesulfonyl (Trisyl) group is employed to protect amines and alcohols, offering advantages in selectivity and deprotection conditions.
• Catalyst & Ligand Development: Utilized in the synthesis of chiral sulfonamide ligands and organocatalysts for asymmetric synthesis.
• Chemical Research & Development: A fundamental tool in academic and industrial R&D labs for exploring new synthetic methodologies and constructing complex molecular architectures.

Basic Information

Product Name	2,4,6-Triisopropylbenzenesulfonyl Chloride
CAS No.	6553-96-4
Molecular Formula	C15H23ClO2S
Molecular Weight	302.86 g/mol
Synonyms	Trisyl Chloride; 2,4,6-Triisopropylbenzenesulfonyl chloride; 1,3,5-Triisopropyl-2-(chlorosulfonyl)benzene; 2,4,6-Triisopropyldiazosulfonyl Chloride; Trisyl-Cl; TIPS-Cl (context-dependent); Benzenesulfonyl chloride, 2,4,6-triisopropyl-
EINECS	229-476-3

Quality Control

Our 2,4,6-Triisopropylbenzenesulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high chemical purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or lumps
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	92 - 96 °C
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.