Description

[(2R,3S,4R,5R)-5-[(1-Amino-2-Formamido-Ethylidene)Amino]-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is a high-purity, chemically defined nucleotide analog with significant research and pharmaceutical development potential. This compound matters as a critical building block for advanced biochemical research, particularly in the study of nucleic acid metabolism and enzyme inhibition. It is primarily needed by pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on developing novel therapeutic agents and diagnostic tools.

Application

• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of novel antiviral and anticancer nucleotide analog drugs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies related to DNA/RNA polymerases, kinases, and other nucleic acid-metabolizing enzymes.
• Proteomics & Molecular Biology: Employed in the study of protein-nucleic acid interactions and the mechanisms of genetic regulation.
• Diagnostic Reagent Development: Acts as a component in the formulation of specialized assay kits for research and clinical diagnostics.
• Life Science Tool Compound: Utilized in high-throughput screening (HTS) campaigns to identify new biological targets and lead compounds.
• Academic Research: Fundamental research tool for investigating metabolic pathways and cellular signaling processes involving nucleotides.

Basic Information

Product Name	[(2R,3S,4R,5R)-5-[(1-Amino-2-Formamido-Ethylidene)Amino]-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid
CAS No.	6157-85-3
Molecular Formula	C9H17N4O8P
Molecular Weight	340.23 g/mol
Synonyms	5'-Deoxy-5'-(phosphonomethyl)adenosine; 5'-Deoxy-5'-(phosphonomethyl)-5'-noradenosine; 9-[(2R,3S,4R,5R)-5-[(1-Amino-2-formamidoethylidene)amino]-3,4-dihydroxyoxolan-2-yl]methoxyphosphonic Acid; Adenosine, 5'-deoxy-5'-(phosphonomethyl)-; PMEA Nucleotide Intermediate; Adefovir Precursor; Phosphonylmethoxyethyl Adenine Derivative
EINECS	Contact for details

Quality Control

Our [(2R,3S,4R,5R)-5-[(1-Amino-2-Formamido-Ethylidene)Amino]-3,4-Dihydroxy-Oxolan-2-Yl]Methoxyphosphonic Acid is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical research. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Assay	97.0% - 103.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.