Description

Harmine Hydrochloride Dihydrate is a high-purity, crystalline alkaloid salt derivative of harmine. This compound is valued for its consistent quality and stability, making it a critical reference standard and intermediate in advanced research and development. It is primarily utilized by the pharmaceutical, biotechnology, and academic research sectors for applications in neuroscience, biochemistry, and medicinal chemistry.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel therapeutic agents.
• Biochemical Research: Used as a selective inhibitor in enzymatic studies, particularly for investigating monoamine oxidase (MAO) and other biological pathways.
• Neuroscience Studies: Employed in preclinical research to study neuropharmacology, receptor binding, and the mechanisms of central nervous system activity.
• Analytical Chemistry: Functions as a certified reference material (CRM) for method development, validation, and quality control in HPLC, LC-MS, and other analytical techniques.
• Academic & Contract Research: A fundamental reagent for universities and CROs conducting basic and applied research in organic chemistry and pharmacology.

Basic Information

Product Name	Harmine Hydrochloride Dihydrate
CAS No.	6028-02-0
Molecular Formula	C₁₃H₁₂N₂O • HCl • 2H₂O
Molecular Weight	294.73 g/mol
Synonyms	Harmine HCl Dihydrate; 7-Methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride dihydrate; Banisterine hydrochloride dihydrate; Telepathine hydrochloride dihydrate; Yageine hydrochloride dihydrate; 3,4-Dihydro-7-methoxy-1-methyl-9H-pyrido[3,4-b]indole hydrochloride dihydrate; Harmine monohydrochloride dihydrate
EINECS	Contact for details

Quality Control

Our Harmine Hydrochloride Dihydrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification (IR, HPLC), assay (HPLC), and control of related substances and residual solvents, to ensure it meets stringent purity requirements. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; ensure the container is kept tightly sealed after each use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	10.0% - 13.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.