Description

2-(Fluorosulfonyl)Difluoroacetyl Fluoride is a highly reactive fluorinated building block and fluorosulfonylating agent. This compound is critical for introducing the difluoroacetyl and fluorosulfonyl functional groups into target molecules, enabling the synthesis of advanced materials and pharmaceuticals. It is primarily utilized by research chemists and process development scientists in the agrochemical, pharmaceutical, and specialty chemical industries for creating novel compounds with specific biological or physical properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfonyl fluoride or difluoromethyl motifs for bioactivity.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorosulfonyl group enhances stability and efficacy.
• Polymer & Material Science: Serves as a monomer or modifier for creating fluorinated polymers with enhanced chemical resistance, thermal stability, and unique surface properties.
• Lithium-Ion Battery Electrolytes: Potential additive or precursor for novel electrolyte salts aimed at improving battery performance and safety.
• Organic Synthesis Reagent: A versatile reagent for introducing fluorosulfonyl and difluoroacetyl groups in complex organic molecule construction.
• Proteomics Research: Can be used as a reactive handle in chemical biology for labeling proteins or as a warhead in covalent inhibitor design.

Basic Information

Product Name	2-(Fluorosulfonyl)Difluoroacetyl Fluoride
CAS No.	677-67-8
Molecular Formula	C2F4O3S
Molecular Weight	180.07 g/mol
Synonyms	Difluoro(fluorosulfonyl)acetyl Fluoride; Perfluorooxathietan-2-one; Tetrafluorooxathietanone; 2,2-Difluoro-2-(fluorosulfonyl)acetyl Fluoride; Oxathietanone, tetrafluoro-; FSO2CF2C(O)F
EINECS	211-656-4

Quality Control

Every batch of 2-(Fluorosulfonyl)Difluoroacetyl Fluoride is produced and tested under stringent quality management protocols to ensure consistency and reliability for your synthetic processes. Our products undergo rigorous quality testing, including GC and NMR analysis, to ensure compliance with industry standards and customer specifications. Certificates of Analysis (COA) detailing purity and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at temperatures between 2°C and 8°C (refrigerated). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as bases and strong nucleophiles.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (by GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.