Description

Ethylenesulphonyl Fluoride is a highly reactive organosulfur compound featuring a sulfonyl fluoride functional group. This compound serves as a versatile and critical building block in advanced organic synthesis, particularly for the development of pharmaceuticals and agrochemicals. It is essential for researchers and manufacturers in fine chemical, pharmaceutical, and material science industries seeking to introduce sulfonyl fluoride moieties into complex molecules.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor antagonists.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that require the sulfonyl fluoride group for bioactivity.
• Chemical Biology & Proteomics: Acts as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent inhibitors due to its selective reactivity with serine hydrolases and other nucleophilic residues.
• Polymer & Material Science: Employed as a monomer or cross-linking agent for producing specialty polymers with unique surface properties or chemical resistance.
• Sulfur(VI) Fluoride Exchange (SuFEx) Chemistry: A prime substrate in this next-generation click chemistry platform for constructing stable linkages between molecules under mild conditions.
• Ligand & Catalyst Development: Utilized to synthesize novel ligands and organocatalysts containing the sulfonyl fluoride functional group.

Basic Information

Product Name	Ethylenesulphonyl Fluoride
CAS No.	677-25-8
Molecular Formula	C2H3FO2S
Molecular Weight	110.11 g/mol
Synonyms	Ethenesulfonyl fluoride; Ethylene fluorosulfonate; 2-Fluoroethanesulfonyl fluoride; Vinylsulfonyl fluoride; Ethenesulfonic acid fluoride; 1-Fluoro-2-sulfonylethane; Sulfonyl fluoride, ethene-; ESF
EINECS	211-642-4

Quality Control

Every batch of Ethylenesulphonyl Fluoride is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and commercial synthesis. A detailed Certificate of Analysis (COA) specifying identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.