Description

Methyl 3,3,3-Trifluoro-2-Iodopropionate is a versatile fluorinated building block and a key synthon in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoromethyl and iodine functional groups, enabling efficient introduction of fluorine atoms and further functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries seeking to develop novel compounds with enhanced properties.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of fluorinated active pharmaceutical ingredients (APIs), particularly for antiviral and anticancer drug candidates.
• Agrochemical Synthesis: Used to construct fluorinated pyrethroids, herbicides, and other crop protection agents that benefit from improved metabolic stability and bioavailability.
• Material Science Monomer: Serves as a building block for specialty polymers and liquid crystals, where the CF3 group can modify surface energy and optical properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to form complex molecular architectures.
• Fluorine Chemistry Research: A valuable reagent for studying nucleophilic substitution and radical reactions involving fluorinated centers in academic and industrial R&D settings.
• Labeling and Tracer Compounds: Potential use in creating fluorinated probes or radiolabeled compounds for imaging and diagnostic applications.

Basic Information

Product Name	Methyl 3,3,3-Trifluoro-2-Iodopropionate
CAS No.	666-93-3
Molecular Formula	C4H4F3IO2
Molecular Weight	267.97 g/mol
Synonyms	Methyl 2-Iodo-3,3,3-trifluoropropionate; 3,3,3-Trifluoro-2-iodopropionic Acid Methyl Ester; 2-Iodo-3,3,3-trifluoropropionic Acid Methyl Ester; Methyl α-Iodo-β,β,β-trifluoropropionate; Methyl β,β,β-Trifluoro-α-iodopropionate; MFIPA; MTFIP
EINECS	Contact for details

Quality Control

Our Methyl 3,3,3-Trifluoro-2-Iodopropionate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopy (NMR, IR), to ensure high purity and consistent performance. Certificates of Analysis (COA) with detailed specifications are provided for every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider using amber glass containers under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.