Description

4-(Trifluoromethoxy)Benzaldehyde is a versatile aromatic aldehyde building block characterized by a benzaldehyde core substituted with a trifluoromethoxy group at the para position. This compound is valued for its unique combination of aromatic reactivity and the electron-withdrawing, lipophilic properties imparted by the trifluoromethoxy moiety, making it a critical intermediate in advanced synthesis. It is primarily sought after by research and development teams and process chemists in the pharmaceutical and agrochemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in developing compounds with improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethoxy group enhances biological activity.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of specialty chemicals for electronic displays and organic light-emitting diodes.
• Organic Synthesis & Research: A valuable reagent for introducing the 4-(trifluoromethoxy)benzyl moiety via reactions such as reductive amination, Grignard reactions, or oxidation/reduction sequences.
• Coordination Chemistry & Ligand Design: Used to synthesize novel ligands for catalysis and material science applications.
• Fine Chemical Production: Intermediate in the manufacture of dyes, flavors, and other performance chemicals.

Basic Information

Product Name	4-(Trifluoromethoxy)Benzaldehyde
CAS No.	659-28-9
Molecular Formula	C8H5F3O2
Molecular Weight	190.12 g/mol
Synonyms	p-(Trifluoromethoxy)benzaldehyde; 4-(Trifluoromethoxy)benzaldehyde; α,α,α-Trifluoro-p-anisaldehyde; Benzaldehyde, 4-(trifluoromethoxy)-; 1-Trifluoromethoxy-4-formylbenzene; 4-Formylphenyl trifluoromethyl ether; 659-28-9; NSC 221986
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethoxy)Benzaldehyde is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and reducing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.