Description

Benzene, 1-(Difluoromethyl)-4-Methoxy- is a specialized fluorinated aromatic building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethyl and methoxy substituents, enabling precise molecular modifications. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting metabolic and central nervous system diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms can enhance biological activity and environmental stability.
• Liquid Crystal & OLED Material Research: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Advanced Polymer Modification: Employed to introduce fluorine-containing functional groups into polymer backbones to alter surface properties, chemical resistance, and thermal stability.
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring new C-F bond formation reactions and the properties of fluorinated arenes.

Basic Information

Product Name	Benzene, 1-(Difluoromethyl)-4-Methoxy-
CAS No.	658-17-3
Molecular Formula	C8H8F2O
Molecular Weight	158.15 g/mol
Synonyms	1-(Difluoromethyl)-4-methoxybenzene; 4-Methoxybenzylidene difluoride; p-Methoxy-α,α-difluorotoluene; (Difluoromethyl)-4-methoxybenzene; 4-Methoxybenzyl Difluoride; α,α-Difluoro-4-methoxytoluene; 4-Methoxybenzal Difluoride; p-(Difluoromethyl)anisole
EINECS	Contact for details

Quality Control

Every batch of Benzene, 1-(Difluoromethyl)-4-Methoxy- is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, ensuring traceability and consistency for your critical R&D and scale-up processes. Our quality systems are designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its nature as a fluoride/strong alkali reactive and highly volatile compound, keep away from incompatible materials and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.