Description

Pentafluorobenzyl Chloride is a versatile and highly reactive organofluorine building block, primarily valued for its role as a key derivatization reagent in analytical chemistry. Its commercial importance stems from its ability to introduce the pentafluorobenzyl group, which enhances detection sensitivity in techniques like gas chromatography and mass spectrometry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and analytical reagent industries, where precise molecular modification is required.

Application

• Analytical Derivatization Agent: Critical for the sensitive detection and quantification of carboxylic acids, phenols, and other analytes in environmental, food, and biological samples via GC-ECD or GC-MS.
• Pharmaceutical Intermediate: Serves as a key synthon in the synthesis of complex molecules, including active pharmaceutical ingredients (APIs) and diagnostic agents.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the introduction of fluorine atoms can improve efficacy and environmental profile.
• Liquid Crystal & Electronic Materials: Acts as a precursor in the manufacture of fluorinated liquid crystals and specialty polymers for electronic applications.
• Cross-coupling Reactions: Employed in palladium-catalyzed reactions, such as Suzuki and Stille couplings, to construct complex biaryl systems.
• Protecting Group Chemistry: Useful for the temporary protection of alcohols and amines during multi-step synthetic sequences.

Basic Information

Product Name	Pentafluorobenzyl Chloride
CAS No.	653-35-0
Molecular Formula	C7H2ClF5
Molecular Weight	216.54 g/mol
Synonyms	2,3,4,5,6-Pentafluorobenzyl Chloride; α-Chloro-2,3,4,5,6-pentafluorotoluene; (Pentafluorophenyl)methyl Chloride; PFB-Cl; Pentafluorobenzylchloride; Perfluorobenzyl Chloride; NSC 5185
EINECS	211-483-5

Quality Control

Our Pentafluorobenzyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.