Description

2,3,5,6-Tetrafluorobenzotrifluoride is a highly fluorinated aromatic building block of significant interest in advanced chemical synthesis. Its unique structure, characterized by multiple fluorine atoms and a trifluoromethyl group, makes it a critical intermediate for introducing fluorinated motifs into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors who require precise fluorination to modulate the biological activity, metabolic stability, and lipophilicity of their products.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs requiring fluorinated aromatic rings to enhance potency and bioavailability.
• Agrochemical Synthesis: Used in the development of modern pesticides and herbicides, where fluorination improves weather resistance, uptake, and target specificity.
• Liquid Crystal & Electronic Materials: Acts as a building block for fluorinated liquid crystals and organic semiconductors, contributing to improved dielectric properties and thermal stability.
• Advanced Polymer Modification: Employed to incorporate fluorine into polymer backbones or side chains, enhancing material properties such as chemical resistance, thermal stability, and low surface energy.
• Organic Synthesis Reagent: Functions as a versatile reagent in cross-coupling reactions and nucleophilic aromatic substitution, enabling the construction of complex, fluorinated organic architectures.

Basic Information

Product Name	2,3,5,6-Tetrafluorobenzotrifluoride
CAS No.	651-80-9
Molecular Formula	C7HF7O
Molecular Weight	246.07 g/mol
Synonyms	2,3,5,6-Tetrafluoro-α,α,α-trifluorotoluene; Perfluorobenzyl Alcohol (incorrect but common alias); 2,3,5,6-Tetrafluoro-α,α,α-trifluoromethylbenzene; 2,3,5,6-Tetrafluorobenzyl Trifluoride; 2,3,5,6-Tetrafluoro-1-(trifluoromethyl)benzene; Benzene, 2,3,5,6-tetrafluoro-1-(trifluoromethyl)-; 1,2,4,5-Tetrafluoro-3-(trifluoromethyl)benzene
EINECS	211-476-5

Quality Control

Our 2,3,5,6-Tetrafluorobenzotrifluoride is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated area away from heat sources and incompatible materials such as strong bases. Due to its highly volatile nature, ensure containers are properly sealed. Recommended storage temperature is 2-8°C for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.