Description

α-Naphthoflavone CAS NO 604-59-1 is a synthetic flavonoid derivative widely recognized as a potent and selective agonist for the aryl hydrocarbon receptor (AhR). This compound is a critical research tool for investigating cellular signaling pathways, xenobiotic metabolism, and immune modulation. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and academic sectors for drug discovery, toxicology studies, and biochemical research.

Application

• Biochemical Research: Used as a selective AhR agonist to study receptor-mediated gene expression, dioxin-like effects, and CYP1A enzyme induction in cell-based assays.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the discovery of novel therapeutics targeting inflammatory diseases and cancer pathways.
• Toxicology & Safety Assessment: Employed to model and understand the mechanisms of action of environmental pollutants and to assess compound toxicity profiles.
• Academic Studies: A key reagent in university and institutional labs for fundamental research into cell biology, immunology, and molecular pharmacology.
• Diagnostic Kit Manufacturing: May be incorporated into specialized assay kits designed to measure AhR activity or screen for receptor ligands.

Basic Information

Product Name	α-Naphthoflavone
CAS No.	604-59-1
Molecular Formula	C19H12O2
Molecular Weight	272.30 g/mol
Synonyms	7,8-Benzoflavone; α-Naphthoflavone; α-NF; ANF; 2-Phenylbenzo[h]chromen-4-one; 2-Phenyl-4H-benzo[h]chromen-4-one; 2-Phenyl-4H-naphtho[1,2-b]pyran-4-one; NSC 220423
EINECS	210-068-9

Quality Control

Our α-Naphthoflavone is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Custom purity grades and analytical packages are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	158°C - 162°C
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.