Description

Gliotoxin CAS NO 67-99-2 is a potent epipolythiodioxopiperazine (ETP) class mycotoxin produced by various fungi, including Aspergillus and Gliocladium species. This secondary metabolite is of significant interest in biomedical and agricultural research due to its well-characterized immunosuppressive and apoptotic properties. It serves as a critical reference standard and biochemical tool for researchers in pharmacology, toxicology, and mycology, enabling the study of fungal pathogenesis, immune cell function, and potential therapeutic applications.

Application

• Biomedical Research: Used as a reference standard and active agent in studies investigating immunosuppression, apoptosis (programmed cell death), and mitochondrial function.
• Pharmacological Studies: Serves as a biochemical tool to explore its mechanism of action, particularly its inhibition of the transcription factor NF-κB and other molecular targets.
• Toxicology & Safety Assessment: Essential for analytical method development and validation to detect and quantify gliotoxin in food, feed, and environmental samples for safety monitoring.
• Mycology & Plant Pathology: Employed in research to understand the role of gliotoxin in fungal virulence and its effects on plant and animal hosts.
• Antifungal Agent Research: Investigated for its own antifungal properties and as a model compound for developing novel antifungal strategies.
• Cell Biology: Utilized to induce specific cellular stress responses and study redox biology due to its disulfide bridge, which is critical for its biological activity.

Basic Information

Product Name	Gliotoxin
CAS No.	67-99-2
Molecular Formula	C13H14N2O4S2
Molecular Weight	326.39 g/mol
Synonyms	Aspergillin; Gliotoxin (from Gliocladium fimbriatum); (-)-Gliotoxin; [1aR-(1aα,4aβ,10aα,10bα)]-2,3,5a,6,10a,10b-Hexahydro-4a,10b-dihydroxy-8-(hydroxymethyl)-1a,4a-dimethyl-7H-oxireno[2',3':4,5]pyrrolo[1,2-a]indole-1,7(1aH)-dione; 3,6-Epidithio-3,6-dihydropiperazine-2,5-dione derivative; ETP Mycotoxin
EINECS	200-670-0

Quality Control

Our Gliotoxin is produced and handled under strict quality-controlled conditions suitable for research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic identification (NMR, MS), to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) containing batch-specific data is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere to minimize oxidation and ensure long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.