Description

Ethyl 6-(Trifluoromethyl)Nicotinate is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in the unique combination of the nicotinate ester moiety and the electron-withdrawing trifluoromethyl group, which imparts enhanced metabolic stability and lipophilicity to target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients with improved properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Building block for creating advanced herbicides, fungicides, and insecticides with the beneficial properties of fluorine atoms.
• Material Science Research: Used in the synthesis of functionalized ligands for catalysis and in the development of novel organic electronic materials.
• Chemical Biology & Proteomics: Serves as a versatile scaffold for designing molecular probes and enzyme inhibitors for biological studies.
• Custom Synthesis & Contract Manufacturing: A pivotal starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	Ethyl 6-(Trifluoromethyl)Nicotinate
CAS No.	597532-36-0
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	Ethyl 6-(trifluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-(trifluoromethyl)-, ethyl ester; 6-(Trifluoromethyl)nicotinic acid ethyl ester; Ethyl 6-(trifluoromethyl)nicotinate; Ethyl 6-trifluoromethylnicotinate; 6-Trifluoromethyl-nicotinic acid ethyl ester; 3-Carbethoxy-6-(trifluoromethyl)pyridine
EINECS	Contact for details

Quality Control

Our production of Ethyl 6-(Trifluoromethyl)Nicotinate adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with every shipment. Our quality system is designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.