Description

Nfat Inhibitor, Cell Permeable CAS NO 592517-80-1 is a potent and selective small molecule inhibitor of the Nuclear Factor of Activated T-cells (NFAT) signaling pathway, designed for cellular research applications. Its cell-permeable nature allows for direct investigation of NFAT-mediated processes in intact cells, making it a critical tool for dissecting immune response, inflammation, and cell development pathways. This compound is essential for researchers and scientists in the fields of immunology, oncology, and molecular biology, particularly for high-throughput screening and target validation studies.

Application

• Immunological Research: Investigation of T-cell activation, cytokine production, and immune response modulation.
• Inflammation Studies: Research into NFAT's role in inflammatory diseases such as rheumatoid arthritis and asthma.
• Oncology Research: Study of NFAT signaling in tumor progression, angiogenesis, and cancer cell survival.
• Cardiovascular Research: Exploration of NFAT's function in cardiac hypertrophy and vascular development.
• Neuroscience: Analysis of NFAT pathways in neuronal development, plasticity, and neurodegenerative conditions.
• High-Throughput Screening (HTS): Utilized as a reference compound in drug discovery campaigns targeting calcineurin-NFAT signaling.
• Mechanistic Studies: Tool for validating the specificity of biological effects mediated by the NFAT transcription factor family.

Basic Information

Product Name	Nfat Inhibitor, Cell Permeable CAS NO 592517-80-1
CAS No.	592517-80-1
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	11R-VIVIT; NFAT Inhibitor XI; (R)-11R-VIVIT; (R)-N-(4-(4-(3-(2-Chloro-4-methoxyphenyl)ureido)phenyl)thiazol-2-yl)piperidine-1-carboxamide; NFATc Inhibitor; VIVIT Peptide Mimetic; Cell-Permeable NFAT Inhibitor; 11R-VIVIT TFA
EINECS	Contact for details

Quality Control

Our Nfat Inhibitor is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research use. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation. Certificates of Analysis (COA) detailing purity, identity, and potency are available upon request.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The compound is stable under these conditions for at least two years.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms to structure (396.46 g/mol)
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Biological Activity (IC₅₀)	Reported value provided with COA

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.