Description

3-Iodo-2-(Trifluoromethyl)Pyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, combining iodine and a trifluoromethyl group on the pyridine ring, makes it an essential intermediate for creating complex molecules with tailored properties. This compound is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly in drug discovery for central nervous system (CNS) and anti-infective agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as charge-transport molecules or fluorinated liquid crystals.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form biaryl and other complex structures.
• Chemical Biology Probes: Useful for labeling and modifying biomolecules in medicinal chemistry and biochemical research due to its reactive halogen site.

Basic Information

Product Name	3-Iodo-2-(Trifluoromethyl)Pyridine
CAS No.	590371-71-4
Molecular Formula	C6H3F3IN
Molecular Weight	272.99 g/mol
Synonyms	2-(Trifluoromethyl)-3-iodopyridine; 3-Iodo-2-trifluoromethylpyridine; Pyridine, 3-iodo-2-(trifluoromethyl)-; 590371-71-4; 3-Iodo-α,α,α-trifluoro-2-picoline
EINECS	Contact for details

Quality Control

Our 3-Iodo-2-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications. Our quality commitment supports applications in cGMP and other regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (GC)	≥97.0%
Melting Point	Contact for details
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.