Description

2,3-Difluoro-5-Chloro Pyridine is a high-purity fluorinated pyridine derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its unique halogenated structure makes it an indispensable building block for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine substituents enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific halogenated aromatic cores.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies for use in custom synthesis projects and scale-up processes under cGMP conditions.

Basic Information

Product Name	2,3-Difluoro-5-Chloro Pyridine
CAS No.	589402-43-7
Molecular Formula	C5H2ClF2N
Molecular Weight	149.53 g/mol
Synonyms	5-Chloro-2,3-difluoropyridine; 2,3-Difluoro-5-chloropyridine; Pyridine, 5-chloro-2,3-difluoro-; 5-Chloro-2,3-difluoro-pyridine; 2,3-Difluor-5-chlorpyridin (German); 2,3-ジフルオロ-5-クロロピリジン (Japanese)
EINECS	Contact for details

Quality Control

Our 2,3-Difluoro-5-Chloro Pyridine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure it meets the high-purity standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.