Description

4-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both a carboxylic acid and a trifluoromethyl group on the pyridine ring, makes it indispensable for creating molecules with tailored electronic and steric properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel agrochemicals, pharmaceuticals, and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chelating ligands and organocatalysts used in asymmetric synthesis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials that require specific fluorine-containing motifs.
• Chemical Biology & Proteomics: Utilized as a building block for designing chemical probes and affinity tags to study biological systems.

Basic Information

Product Name	4-(Trifluoromethyl)Pyridine-2-Carboxylic Acid
CAS No.	588702-62-9
Molecular Formula	C7H4F3NO2
Molecular Weight	191.11 g/mol
Synonyms	2-Pyridinecarboxylic acid, 4-(trifluoromethyl)-; 4-(Trifluoromethyl)picolinic acid; 4-Trifluoromethylpyridine-2-carboxylic acid; 4-CF3-Picolinic Acid; 2-Carboxy-4-trifluoromethylpyridine; α,α,α-Trifluoro-4-picoline-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our 4-(Trifluoromethyl)Pyridine-2-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR), to ensure it meets the high standards required for research and scale-up applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and performance.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.