Description

Ku-55933 is a potent, selective, and cell-permeable inhibitor of the ataxia telangiectasia mutated (ATM) kinase, a key regulator of the DNA damage response. This high-purity compound is essential for advanced biochemical and pharmacological research, enabling precise investigation of DNA repair mechanisms, cell cycle checkpoints, and cancer biology. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, radiobiology, and the development of novel therapeutic strategies.

Application

• Biochemical Research: A critical tool for studying the ATM kinase signaling pathway and its role in the cellular response to double-strand DNA breaks.
• Cancer Biology Studies: Used to investigate tumor cell sensitivity to DNA-damaging agents like ionizing radiation and chemotherapeutics, aiding in the identification of synthetic lethal interactions.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening and target validation for oncology drug candidates.
• Academic Research: Facilitates fundamental research in genetics, radiobiology, and cell cycle regulation within university and institutional laboratories.
• Mechanistic Studies: Enables detailed analysis of checkpoint control, apoptosis, and genomic instability in various cellular models.

Basic Information

Product Name	Ku-55933
CAS No.	587871-26-9
Molecular Formula	C₂₁H₂₂N₄O₄S
Molecular Weight	426.49 g/mol
Synonyms	ATM Kinase Inhibitor; 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one; KU-55933; 2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one; ATM Inhibitor, KU-55933; 6-(Thianthren-1-yl)-2-morpholin-4-yl-4H-pyran-4-one
EINECS	Contact for details

Quality Control

Every batch of Ku-55933 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our products are supported by a detailed Certificate of Analysis (COA) that includes data from HPLC, NMR, and mass spectrometry. We adhere to relevant industry standards for research chemicals, ensuring reliable and reproducible performance for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.