Description

Z-Val-Dl-Asp(Ome)-Fluoromethylketone is a specialized fluoromethyl ketone derivative of a protected aspartic acid dipeptide, serving as a potent and irreversible inhibitor of cysteine proteases. This compound matters for researchers and developers requiring precise biochemical tools to study and modulate protease activity in complex biological systems. It is primarily needed by professionals in pharmaceutical R&D, biochemical research, and proteomics for investigating disease mechanisms and developing novel therapeutic agents.

Application

• Biochemical Research: Used as a selective, irreversible inhibitor for studying the function and mechanism of cysteine proteases like caspases and cathepsins.
• Pharmaceutical Development: Serves as a key pharmacophore or lead compound in the design of drugs targeting protease-mediated diseases, including inflammatory and neurodegenerative conditions.
• Proteomics & Cell Biology: Employed in cell-based assays to selectively inhibit specific protease pathways, aiding in the elucidation of apoptotic and signaling cascades.
• Enzyme Mechanism Studies: A critical tool for kinetic and structural analysis of enzyme-inhibitor interactions due to its reactive fluoromethyl ketone warhead.
• Diagnostic Reagent Development: Potential use in the formulation of diagnostic kits for detecting and quantifying specific protease activities in biological samples.

Basic Information

Product Name	Z-Val-Dl-Asp(Ome)-Fluoromethylketone
CAS No.	582317-87-1
Molecular Formula	C20H27FN2O7
Molecular Weight	426.44 g/mol
Synonyms	Z-Val-Asp(OMe)-FMK; Benzyloxycarbonyl-Val-Asp(OMe)-fluoromethyl ketone; Z-V-A-D(OMe)-FMK; Caspase Inhibitor Z-V-A-D(OMe)-FMK; (2S)-2-[[(2S)-2-[[(2S)-3-Methyl-1-oxo-1-[(phenylmethoxy)amino]butan-2-yl]amino]-4-methoxy-4-oxo-1-oxobutan-2-yl]amino]-3-fluoropropan-1-one; Z-Val-Ala-Asp(OMe)-FMK (common variant reference); Boc-Val-Asp(OMe)-FMK (related protected form); Caspase-3 Inhibitor VI
EINECS	Contact for details

Quality Control

Our Z-Val-Dl-Asp(Ome)-Fluoromethylketone is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and structural confirmation via NMR and Mass Spectrometry. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.