Description

Z-Val-Dl-Asp-Fluoromethylketone is a potent and selective fluoromethylketone-based inhibitor, widely recognized for its role in biochemical research. This compound is critical for studying protease activity and apoptosis pathways, offering researchers a reliable tool for targeted enzyme inhibition. It is primarily utilized by pharmaceutical R&D teams, academic laboratories, and biotechnology companies focused on developing novel therapeutic agents and understanding cellular mechanisms.

Application

• Protease Inhibition Studies: Used as a specific inhibitor for caspases and other cysteine proteases in biochemical assays.
• Apoptosis Research: A key reagent for investigating programmed cell death pathways and related signaling cascades.
• Drug Discovery & Development: Serves as a lead compound or pharmacophore model for designing new therapeutic agents targeting inflammatory and neurodegenerative diseases.
• Enzyme Mechanism Analysis: Employed to elucidate the catalytic mechanisms and substrate specificities of various proteases.
• Biomarker Development: Used in the development of diagnostic assays and probes for detecting specific protease activity in biological samples.
• High-Throughput Screening (HTS): Utilized as a reference standard in screening libraries for identifying new protease inhibitors.

Basic Information

Product Name	Z-Val-Dl-Asp-Fluoromethylketone
CAS No.	582316-00-5
Molecular Formula	C20H26F2N2O6
Molecular Weight	428.43 g/mol
Synonyms	Z-VD-FMK; Z-Val-Asp(OMe)-FMK; Benzyloxycarbonyl-Val-Asp(OMe)-fluoromethyl ketone; Caspase Inhibitor Z-VD-FMK; Z-Val-DL-Asp-fluoromethylketone; (Benzyloxycarbonyl)valyl-aspartyl-fluoromethyl ketone; Z-VD(OMe)-FMK; Z-Val-Asp(OMe)-CH2F
EINECS	Contact for details

Quality Control

Our Z-Val-Dl-Asp-Fluoromethylketone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and NMR for structural confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.