Description

P38 Map Kinase Inhibitor III is a potent and selective small molecule inhibitor targeting the p38 MAP kinase signaling pathway. This compound is a critical research tool for investigating cellular stress responses, inflammation, and apoptosis in biochemical and pharmacological studies. It is essential for academic researchers, pharmaceutical R&D teams, and biotechnology companies engaged in drug discovery and signal transduction research.

Application

• Biochemical Research: Used as a selective inhibitor to study the role of p38 MAPK in cellular signaling cascades and stress response pathways.
• Drug Discovery & Development: Serves as a key reference compound and pharmacological tool for screening and validating new anti-inflammatory or cytoprotective drug candidates.
• Cell Biology Studies: Applied in in vitro assays to elucidate mechanisms of inflammation, apoptosis, cell differentiation, and cytokine production.
• Target Validation: Utilized to confirm the biological function and therapeutic potential of p38 MAPK in various disease models, including autoimmune disorders and neurodegenerative conditions.
• Academic Research: A fundamental reagent for universities and research institutes conducting fundamental research on kinase biology and intracellular communication.

Basic Information

Product Name	P38 Map Kinase Inhibitor III
CAS No.	581098-48-8
Molecular Formula	C₂₀H₂₅N₅O₂
Molecular Weight	367.45 g/mol
Synonyms	SB 203580 Hydrochloride; SB203580 HCl; 4-[5-(4-Fluorophenyl)-2-[4-(methylsulfinyl)phenyl]-1H-imidazol-4-yl]pyridine hydrochloride; p38 MAP Kinase Inhibitor SB203580; SB 203580; SKF 86002; 1H-Imidazole, 4-(4-pyridinyl)-5-(4-fluorophenyl)-2-(4-(methylsulfinyl)phenyl)-, hydrochloride (1:1)
EINECS	Contact for details

Quality Control

Our P38 Map Kinase Inhibitor III is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant quality standards for research chemicals, ensuring reliability for your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.