Description

Bax Inhibitor Peptide P5 is a synthetic cell-permeable pentapeptide designed to specifically inhibit the pro-apoptotic protein Bax. This compound is a critical research tool for studying the intrinsic pathway of apoptosis and cellular stress responses. It is primarily utilized by researchers in the fields of oncology, neurobiology, and pharmacology to investigate cell death mechanisms and develop novel therapeutic strategies. The product is supplied with the CAS Registry Number 579492-83-4.

Application

• Apoptosis Research: A key reagent for investigating the molecular mechanisms of Bax-mediated mitochondrial apoptosis in various cell lines.
• Neuroprotection Studies: Used in models of neurodegenerative diseases (e.g., Alzheimer's, Parkinson's) to inhibit neuronal cell death.
• Cardioprotection Research: Applied in ischemia-reperfusion injury models to study the role of Bax in cardiac myocyte apoptosis.
• Oncology & Drug Discovery: Serves as a control or tool compound in screening for pro-survival drugs that target the Bcl-2 protein family interactions.
• Biochemical Assay Development: Used to validate assays measuring Bax activation, cytochrome c release, or caspase activity.
• Stem Cell Research: Employed to enhance the survival of stem cells during differentiation or transplantation by inhibiting unwanted apoptosis.

Basic Information

Item	Detail
Product Name	Bax Inhibitor Peptide P5
CAS No.	579492-83-4
Molecular Formula	C30H47N9O7
Molecular Weight	645.8 g/mol
Synonyms	Bax Inhibiting Peptide V5; P5 Peptide; Bax Inhibitor, P5; H-Val-Pro-Met-Leu-Lys-OH; VPM-LK; BIP-V5; Pentapeptide P5; Bax Channel Blocker
EINECS	Contact for details

Quality Control

Every batch of Bax Inhibitor Peptide P5 is manufactured and analyzed under strict quality protocols to ensure the highest standards of purity and biological activity for research applications. Our quality commitment includes comprehensive analytical testing, with Certificates of Analysis (COA) provided for each shipment, detailing purity, identity, and content. We adhere to relevant quality management standards to guarantee batch-to-batch consistency and reliability for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (Content)	≥ 98%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.