Description

Rna Polymerase Iii Inhibitor CAS NO 577784-91-9 is a potent and selective small-molecule inhibitor designed for biochemical and pharmacological research. This compound is critical for studying the mechanisms of transcription and gene regulation, specifically targeting RNA Polymerase III activity. It is an essential tool for researchers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on oncology, virology, and fundamental molecular biology.

Application

• Biochemical Research: Used as a specific inhibitor to study the function and inhibition mechanisms of RNA Polymerase III in in vitro transcription assays.
• Cancer Research: Investigated for its potential to suppress the synthesis of tRNAs and other Pol III transcripts, which are often upregulated in cancer cells.
• Virology Studies: Applied in research to understand viral replication processes that hijack host Pol III machinery.
• Signal Transduction Analysis: Utilized to dissect cellular signaling pathways that regulate Pol III-dependent transcription.
• Drug Discovery & Screening: Serves as a reference compound or positive control in high-throughput screening campaigns for novel transcription inhibitors.
• Cell Biology: Employed in cell-based assays to examine the effects of Pol III inhibition on cell growth, proliferation, and metabolism.

Basic Information

Product Name	Rna Polymerase Iii Inhibitor
CAS No.	577784-91-9
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	ML-60218; RNA Polymerase III Inhibitor, ML-60218; ML 60218; ML60218; Pol III Inhibitor; RNA Pol III Inhibitor; Transcription Inhibitor ML-60218
EINECS	Contact for details

Quality Control

Our Rna Polymerase Iii Inhibitor is produced under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.