Description

4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Sulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate and versatile sulfonyl chloride building block. This compound is critical for the synthesis of novel active pharmaceutical ingredients (APIs) and agrochemicals, offering a reactive handle for creating sulfonamide and sulfonate derivatives. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for lead optimization and scale-up activities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of potential drug candidates, particularly in medicinal chemistry programs targeting various disease pathways.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging the bioactive thiazole and sulfonamide motifs.
• Sulfonamide Library Production: Serves as a crucial reagent for high-throughput synthesis and the creation of diverse sulfonamide-based compound libraries for screening.
• Chemical Biology Probes: Employed in the development of chemical probes and tools for studying biological processes and target validation.
• Material Science Research: Potential precursor for functional polymers or advanced materials requiring specific sulfonyl chloride chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Sulfonyl Chloride
CAS No.	568577-83-3
Molecular Formula	C11H7F3N1O2S2Cl1
Molecular Weight	325.76 g/mol
Synonyms	5-(Chlorosulfonyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole; 2-(4-Trifluoromethylphenyl)-4-methyl-1,3-thiazole-5-sulfonyl chloride; 4-Methyl-2-(4-trifluoromethylphenyl)thiazole-5-sulfonyl chloride; 4-Methyl-2-(α,α,α-trifluoro-p-tolyl)thiazole-5-sulfonyl chloride; Thiazole-5-sulfonyl chloride, 4-methyl-2-[4-(trifluoromethyl)phenyl]-; CAS 568577-83-3
EINECS	Contact for details

Quality Control

Our 4-Methyl-2-[4-(Trifluoromethyl)Phenyl]-1,3-Thiazole-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports applications from research to development scale, with the capability to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Recommended long-term storage temperature is 2-8°C (refrigerated). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.