Description

Tmem16Ainhibitorsrevealtmem16A(T16Ainh-A01) CAS NO 552309-42-9 is a potent and selective small-molecule inhibitor of the TMEM16A (anoctamin 1) calcium-activated chloride channel. This compound matters as a critical pharmacological tool for elucidating the physiological and pathological roles of TMEM16A in various cellular processes and disease models. It is primarily needed by researchers and developers in pharmaceutical R&D, academic biochemistry and physiology laboratories, and contract research organizations (CROs) focused on ion channel biology, cystic fibrosis, asthma, gastrointestinal motility disorders, and certain cancers.

Application

• Pharmacological Research Tool: Used to study the function and modulation of the TMEM16A/ANO1 chloride channel in vitro and ex vivo.
• Target Validation: Supports drug discovery programs by validating TMEM16A as a therapeutic target for specific diseases.
• Cystic Fibrosis Research: Investigated in studies exploring alternative chloride channel pathways and potential therapeutic strategies.
• Respiratory Disease Models: Applied in research on asthma, chronic obstructive pulmonary disease (COPD), and bronchial hyperresponsiveness where TMEM16A is implicated.
• Gastrointestinal Physiology Studies: Utilized to examine the role of TMEM16A in smooth muscle contraction, secretion, and interstitial cells of Cajal.
• Cancer Biology Research: Employed in studies investigating the contribution of TMEM16A to tumor progression, including in head and neck squamous cell carcinoma and gastrointestinal stromal tumors (GIST).
• Neuroscience Research: Used to probe the role of chloride channels in neuronal and synaptic function.

Basic Information

Item	Details
Product Name	Tmem16Ainhibitorsrevealtmem16A(T16Ainh-A01)
CAS No.	552309-42-9
Molecular Formula	C23H21N3O3S
Molecular Weight	419.50 g/mol
Synonyms	T16Ainh-A01; Ano1 Inhibitor; TMEM16A Inhibitor; 2-[(5-Ethyl-1,6-dihydro-4-methyl-6-oxo-2-pyrimidinyl)thio]-N-[4-(4-methoxyphenyl)-2-thiazolyl]acetamide; Benzenepropanamide, α-[[(5-ethyl-4-methyl-6-oxo-1,6-dihydro-2-pyrimidinyl)thio]acetyl]amino]-4-methoxy-N-2-thiazolyl-; A01 Inhibitor; Calcium-Activated Chloride Channel Inhibitor
EINECS	Contact for details

Quality Control

Our T16Ainh-A01 is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization including HPLC for purity assessment, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive). For long-term storage, consider under an inert atmosphere. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.