Description

Ulodesine is a high-purity, small-molecule pharmaceutical intermediate with significant therapeutic potential. This compound is valued for its role as a potent and selective inhibitor of purine nucleoside phosphorylase (PNP), making it a critical building block in advanced medicinal chemistry research. It is primarily utilized by pharmaceutical R&D teams and fine chemical manufacturers engaged in developing novel treatments for T-cell malignancies, autoimmune disorders, and other immune-mediated diseases.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel PNP inhibitor drug candidates.
• Biochemical Research: Used as a reference standard and tool compound in enzymatic assays to study purine metabolism and immune cell function.
• Preclinical Development: Serves as a critical material for pharmacokinetic, pharmacodynamic, and toxicology studies in drug discovery pipelines.
• Process Chemistry: Employed in route scouting and optimization for the scalable production of active pharmaceutical ingredients (APIs).
• Academic Research: Utilized in university and institutional labs for fundamental research in immunology and oncology.

Basic Information

Product Name	Ulodesine
CAS No.	548486-59-5
Molecular Formula	C₁₀H₁₃N₅O₃
Molecular Weight	251.24 g/mol
Synonyms	BCX-1777; Forodesine; (3R,4S)-1-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-4-hydroxy-5-(4-methoxybenzyl)pyrrolidin-3-yl] 4-amino-1H-imidazole-4-carboxamide; Immucillin H; PNP Inhibitor BCX-1777; Ulodesine hydrochloride (if applicable, salt form).
EINECS	Contact for details

Quality Control

Our Ulodesine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP guidelines for advanced intermediates and can provide material for regulatory filings upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.