Description

Isrib CAS NO 548470-11-7 is a potent and selective small-molecule inhibitor of the integrated stress response (ISR) pathway. This compound is a critical research tool for investigating cellular stress mechanisms and their implications in neurodegenerative diseases, aging, and cognitive function. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neurobiology, translational medicine, and drug discovery.

Application

• Neurobiology Research: Used to study and modulate the integrated stress response in models of neurodegeneration, such as Alzheimer's, Parkinson's, and traumatic brain injury.
• Cognitive Function Studies: Investigated for its potential to reverse cognitive deficits and enhance memory formation in preclinical research.
• Pharmaceutical Screening: Serves as a reference compound and a key tool in high-throughput screening assays to identify novel ISR pathway modulators.
• Translational Medicine: Employed in proof-of-concept studies to explore therapeutic interventions for stress-related pathologies and aging.
• Cell Biology: Used to dissect the molecular mechanisms of eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and its downstream effects.

Basic Information

Product Name	Isrib
CAS No.	548470-11-7
Molecular Formula	C₂₄H₂₀F₃N₃O₂
Molecular Weight	439.43 g/mol
Synonyms	ISRIB; ISRIB (trans-isomer); Integrated Stress Response Inhibitor; 2-[(1R,2R,3S,5R)-3-(4-Fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]oct-2-yl]-7-(2-methylpyrimidin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine; trans-ISRIB; GSK2606414 inhibitor analog
EINECS	Contact for details

Quality Control

Our Isrib is manufactured under strict quality management systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing including HPLC, NMR, and mass spectrometry for identity confirmation and purity verification. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.