Description

JWH 149 is a synthetic cannabinoid receptor ligand of significant interest in pharmacological and biochemical research. This compound is a critical tool for scientists investigating the endocannabinoid system, its signaling pathways, and potential therapeutic targets. Researchers in pharmaceutical development, neuroscience, and analytical chemistry rely on high-purity reference standards like JWH 149 CAS NO 548461-82-1 for method development, receptor binding studies, and quality control testing.

Application

• Pharmacological Research: Used as a reference standard in receptor binding assays and functional studies to characterize cannabinoid receptor (CB1/CB2) activity and selectivity.
• Analytical Chemistry: Serves as a certified reference material (CRM) for the development and validation of analytical methods, including HPLC, GC-MS, and LC-MS/MS, for forensic and clinical toxicology.
• Biochemical Studies: Employed in vitro to study the downstream effects of cannabinoid receptor activation on cellular signaling cascades and gene expression.
• Pharmaceutical Development: Acts as a chemical scaffold or lead compound in the discovery and optimization of novel therapeutics targeting the endocannabinoid system.
• Forensic Science: Provides a key standard for the identification and quantification of synthetic cannabinoids in seized materials and biological samples.
• Academic Research: Utilized in university and institutional labs for fundamental research into the physiological and pathological roles of cannabinoid receptors.

Basic Information

Product Name	JWH 149
CAS No.	548461-82-1
Molecular Formula	C25H25NO
Molecular Weight	355.48 g/mol
Synonyms	(1-Pentyl-1H-indol-3-yl)(2,2,3,3-tetramethylcyclopropyl)methanone; 1-Pentyl-3-(2,2,3,3-tetramethylcyclopropanoyl)indole; JWH-149; AM-2201 benzimidazole analog (common misnomer); Tetramethylcyclopropylindole
EINECS	Contact for details

Quality Control

Our JWH 149 is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, NMR and IR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications. We are committed to supplying materials that meet the exacting standards required for scientific reproducibility.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.