Description

Bms-345541 is a potent and selective small molecule inhibitor of the IκB kinase (IKK) complex, specifically targeting the IKK-2/IKKβ isoform. This compound is a critical research tool for studying the NF-κB signaling pathway, which plays a central role in inflammation, immunity, and cell survival. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for drug discovery, target validation, and mechanistic studies in areas such as oncology, immunology, and inflammatory diseases.

Application

• Biochemical Research: A key reagent for in vitro studies to elucidate the role of the NF-κB pathway in cellular processes.
• Drug Discovery & Development: Used as a reference standard and pharmacological tool in high-throughput screening and lead optimization for anti-inflammatory and anti-cancer therapeutics.
• Target Validation: Employed to confirm the biological function of IKKβ and assess its viability as a therapeutic target in various disease models.
• Academic Research: Facilitates fundamental research in molecular biology, immunology, and signal transduction mechanisms.
• Inflammation & Immunology Studies: Used to investigate the molecular basis of inflammatory responses and immune regulation.
• Oncology Research: Applied in cancer research to study the contribution of NF-κB signaling to tumorigenesis, proliferation, and resistance to apoptosis.

Basic Information

Product Name	Bms-345541
CAS No.	547757-23-3
Molecular Formula	C₂₂H₂₁N₅O₂
Molecular Weight	387.44 g/mol
Synonyms	BMS-345541; 4(2'-Aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline; IKK-2 Inhibitor V; IKKβ Inhibitor BMS-345541; NF-κB Activation Inhibitor IV; 1,8-Dimethyl-4-[(2-methyl-1H-imidazol-1-yl)methyl]imidazo[1,2-a]quinoxaline; (1,8-Dimethylimidazo[1,2-a]quinoxalin-4-yl)-N-(2-aminoethyl)amine
EINECS	Contact for details

Quality Control

Our Bms-345541 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/LC-MS for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.