Description

Amg 9810 is a potent and selective TRPV1 (Transient Receptor Potential Vanilloid 1) channel antagonist, identified by the CAS number 545395-94-6. This compound is a critical research tool for investigating pain signaling pathways and developing novel analgesic therapeutics. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience and pain management.

Application

• Neuroscience Research: A key pharmacological agent for studying the role of TRPV1 receptors in nociception (pain perception), neurogenic inflammation, and thermal sensation.
• Analgesic Drug Discovery: Serves as a reference standard and lead compound in the development of new non-opioid pain relievers targeting chronic pain conditions.
• In Vitro & In Vivo Studies: Used in cell-based assays and animal models to validate TRPV1 as a therapeutic target and to assess the efficacy of novel antagonists.
• Mechanistic Pharmacology: Employed to elucidate downstream signaling pathways activated by capsaicin and other TRPV1 agonists.
• Biomarker Research: Useful in studies exploring TRPV1 expression and function in various disease states beyond pain, such as migraine, cough, and bladder disorders.

Basic Information

Product Name	Amg 9810
CAS No.	545395-94-6
Molecular Formula	C19H21N3O3S
Molecular Weight	371.45 g/mol
Synonyms	AMG-9810; (E)-N-(4-tert-Butylbenzyl)-3-(quinolin-4-yl)acrylamide; 4-tert-Butyl-N-[(E)-3-(quinolin-4-yl)prop-2-enoyl]benzylamine; TRPV1 Antagonist AMG 9810; Capsazepine analog; Vanilloid receptor antagonist
EINECS	Contact for details

Quality Control

Our Amg 9810 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. For short-term use, the material may be stored at 2-8°C. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.