Description

4-Chlorobenzene-D4-Sulfonamide is a deuterated derivative of 4-chlorobenzenesulfonamide, where four hydrogen atoms are replaced with deuterium, a stable isotope of hydrogen. This isotopic labeling is critical for applications requiring precise molecular tracking, such as in quantitative mass spectrometry and metabolic studies, where it serves as an internal standard to ensure analytical accuracy and reliability. It is primarily utilized by researchers and manufacturers in the pharmaceutical, agrochemical, and analytical chemistry sectors for drug development, environmental analysis, and advanced material science.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard in liquid chromatography-tandem mass spectrometry for the precise quantification of sulfonamide drugs and their metabolites in biological matrices.
• Pharmaceutical Research: Employed in drug metabolism and pharmacokinetics (DMPK) studies to trace the absorption, distribution, metabolism, and excretion of parent compounds.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for calibrating analytical instruments and validating testing methods in quality control laboratories.
• Metabolite Identification: Aids in the structural elucidation and identification of drug metabolites during the development of new chemical entities.
• Environmental Monitoring: Used in trace analysis to detect and quantify sulfonamide antibiotic residues in environmental water samples.
• Isotope Dilution Mass Spectrometry (IDMS): Critical component in IDMS protocols, a definitive method for achieving high accuracy and minimizing matrix effects in complex sample analysis.

Basic Information

Product Name	4-Chlorobenzene-D4-Sulfonamide
CAS No.	544686-14-8
Molecular Formula	C6D4ClNO2S
Molecular Weight	195.66 g/mol
Synonyms	4-Chlorobenzenesulfonamide-d4; p-Chlorobenzenesulfonamide-d4; Benzenesulfonamide, 4-chloro-, tetradeuterio-; 4-Chloro-D4-benzenesulfonamide; Deuterated 4-Chlorobenzenesulfonamide; 4-CBSA-d4; Sulfonamide-d4, 4-chlorobenzene-; Tetradeuterio-4-chlorobenzenesulfonamide
EINECS	Contact for details

Quality Control

Our 4-Chlorobenzene-D4-Sulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C) for structural confirmation and deuterium incorporation, and HPLC for chemical and isotopic purity assessment. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the exact specifications and test results. We ensure compliance with relevant standards for high-purity reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure (Deuterium content ≥98 atom % D)
Purity (HPLC)	≥98.0% (Chemical Purity)
Isotopic Purity	≥98 atom % D
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.