Description

3-Butyn-2-Ol,4-(2-Fluoro-4-Pyridinyl)-(9Ci) is a specialized fluorinated pyridine derivative and a key alkyne-containing building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for applications such as click chemistry, cross-coupling reactions, and as a precursor for novel heterocyclic systems.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting kinase inhibitors and other biologically active molecules.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the fluoropyridine moiety for enhanced biological activity and metabolic stability.
• Material Science: Serves as a monomer or cross-linking agent in the creation of advanced polymers and functional materials with tailored properties.
• Click Chemistry Reagent: The alkyne functional group makes it an ideal participant in copper-catalyzed azide-alkyne cycloaddition (CuAAC) reactions for bioconjugation and polymer modification.
• Ligand Synthesis: Utilized in the preparation of sophisticated ligands for catalysis, including those used in asymmetric synthesis and transition metal catalysis.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes for studying biological processes and target engagement.

Basic Information

Product Name	3-Butyn-2-Ol,4-(2-Fluoro-4-Pyridinyl)-(9Ci)
CAS No.	544676-01-9
Molecular Formula	C9H8FNO
Molecular Weight	165.16 g/mol
Synonyms	4-(2-Fluoro-4-pyridinyl)-3-butyn-2-ol; 3-Butyn-2-ol, 4-(2-fluoro-4-pyridinyl)-; 4-(2-Fluoropyridin-4-yl)but-3-yn-2-ol; 2-Fluoro-4-(1-hydroxybut-3-yn-2-yl)pyridine; (RS)-4-(2-Fluoropyridin-4-yl)but-3-yn-2-ol; (±)-4-(2-Fluoropyridin-4-yl)but-3-yn-2-ol
EINECS	Contact for details

Quality Control

Our 3-Butyn-2-Ol,4-(2-Fluoro-4-Pyridinyl)-(9Ci) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), impurity profile, and physical properties are provided and available upon request. We support cGMP standards for advanced intermediate production where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 97.0%
Purity (HPLC, Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.