Description

(2-Chloro-4-Fluorophenyl)Methanesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its value lies in its dual functional groups, enabling precise chemical modifications to create complex molecular architectures. This intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides.
• Material Science Research: Serves as a monomer or cross-linking agent in the creation of specialized polymers and functional materials.
• Chemical Biology: Employed in the design and synthesis of molecular probes and enzyme inhibitors for biochemical research.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs for client-specific molecule development.

Basic Information

Item	Detail
Product Name	(2-Chloro-4-Fluorophenyl)Methanesulfonyl Chloride
CAS No.	541528-45-4
Molecular Formula	C7H5Cl2FO2S
Molecular Weight	247.08 g/mol
Synonyms	2-Chloro-4-fluorophenyl methanesulfonyl chloride; 1-Chloro-2-(chloromethylsulfonyl)-5-fluorobenzene; Methanesulfonyl chloride, (2-chloro-4-fluorophenyl)-; (2-Chloro-4-fluorobenzene)sulfonyl chloride, methyl-; α-Chloro-2-chloro-4-fluorobenzenemethanesulfonate; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (2-Chloro-4-Fluorophenyl)Methanesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high purity and batch-to-batch consistency. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided to guarantee compliance with your research and production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.