Description

3-[2-(Trifluoromethyl)Pyridin-5-Yl]Propanoic Acid is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise introduction of the trifluoromethyl group and pyridine moiety, which are pivotal for modulating the physicochemical and biological properties of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced metabolic stability, bioavailability, and potency.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in oncology, central nervous system (CNS), and anti-infective drug discovery programs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis for asymmetric synthesis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and organic electronic materials due to its unique electronic properties.
• Chemical Biology Probe: Utilized as a building block for labeling reagents and molecular probes to study biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A fundamental starting material for custom synthesis services catering to specific client R&D and scale-up projects.

Basic Information

Product Name	3-[2-(Trifluoromethyl)Pyridin-5-Yl]Propanoic Acid
CAS No.	539855-70-4
Molecular Formula	C9H8F3NO2
Molecular Weight	219.16 g/mol
Synonyms	5-(2-Carboxyethyl)-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)-5-pyridinepropanoic Acid; 3-[5-Pyridyl-2-(trifluoromethyl)]propionic Acid; 3-(2-Trifluoromethylpyridin-5-yl)propanoic Acid; 3-(2-(Trifluoromethyl)pyridin-5-yl)propanoic acid; β-(2-Trifluoromethyl-5-pyridyl)propionic Acid; 539855-70-4
EINECS	Contact for details

Quality Control

Our 3-[2-(Trifluoromethyl)Pyridin-5-Yl]Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and compliance with REACH regulations ensures a reliable supply of high-purity material for your most demanding applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.