Description

15-Deoxy-δ12,14-Prostaglandin J2 Glutathione is a specialized bioactive conjugate formed from the cyclopentenone prostaglandin 15d-PGJ2 and the endogenous antioxidant glutathione. This compound is a critical research tool for studying cellular signaling pathways related to inflammation, oxidative stress, and apoptosis. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for investigating the role of electrophilic lipid mediators and their interactions with cellular thiols.

Application

• Biochemical Research: A key reagent for studying the anti-inflammatory and pro-resolving effects mediated by the activation of the Nrf2 pathway and inhibition of NF-κB.
• Cell Signaling Studies: Used to investigate the covalent modification of Keap1 and other cysteine-rich proteins, leading to cytoprotective gene expression.
• Pharmaceutical Development: Serves as a reference standard and a lead compound in the development of novel therapeutics targeting inflammatory diseases, metabolic disorders, and neurodegenerative conditions.
• Metabolomics & Lipidomics: Employed as an analytical standard for the identification and quantification of electrophilic lipid-protein adducts in complex biological samples.
• Apoptosis Research: Utilized to explore the dual role of cyclopentenone prostaglandins in inducing programmed cell death in cancer cells while protecting normal cells.

Basic Information

Product Name	15-Deoxy-δ12,14-Prostaglandin J2 Glutathione
CAS No.	537695-15-1
Molecular Formula	C30H45N3O10S
Molecular Weight	639.76 g/mol
Synonyms	15-Deoxy-δ12,14-PGJ2-GSH; 15d-PGJ2-Glutathione Adduct; 15-Deoxy-δ-12,14-prostaglandin J2 glutathione conjugate; 9,10-Didehydro-15-deoxy-δ12,14-PGJ2-Glutathione; 15-Deoxy-δ12,14-prostaglandin J2 linked to glutathione; PGJ2-GSH; Electrophilic lipid-glutathione conjugate
EINECS	Contact for details

Quality Control

Our 15-Deoxy-δ12,14-Prostaglandin J2 Glutathione is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and mass spectrometry, are validated to provide reliable data for our clients in regulated research environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.