Description

Tubacin CAS NO 537049-40-4 is a potent and selective small molecule inhibitor of histone deacetylase 6 (HDAC6). This compound is a critical research tool for investigating the role of HDAC6 in cellular processes such as aggresome formation, microtubule dynamics, and protein degradation. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology, neurodegenerative disease, and immunology research.

Application

• Biomedical Research: A key reagent for studying HDAC6-specific biology, including its function in cell motility, immune synapse formation, and stress response pathways.
• Oncology Studies: Used in vitro and in vivo to explore the therapeutic potential of HDAC6 inhibition in various cancer models, particularly for its role in protein homeostasis and metastasis.
• Neurodegenerative Disease Research: Applied in models of Alzheimer's, Parkinson's, and Huntington's disease to investigate the clearance of misfolded protein aggregates via the HDAC6-dependent aggresome pathway.
• Immunology and Inflammation: Employed to dissect the role of HDAC6 in regulating immune cell function, cytokine production, and inflammatory responses.
• Chemical Biology and Probe Development: Serves as a foundational compound for structure-activity relationship (SAR) studies and the development of novel HDAC6-targeted probes or therapeutics.
• High-Throughput Screening (HTS): Used as a reference standard or positive control in assays designed to discover new HDAC6 modulators.

Basic Information

Product Name	Tubacin
CAS No.	537049-40-4
Molecular Formula	C₂₁H₂₀N₄O₃S
Molecular Weight	408.47 g/mol
Synonyms	Tubacin; HDAC6 Inhibitor, Tubacin; N1-(3-(Dimethylamino)propyl)-N8-hydroxy-2-((naphthalene-1-loxy)methyl)octanediamide; (2R)-N1-[3-(Dimethylamino)propyl]-N8-hydroxy-2-[(1-naphthyloxy)methyl]octanediamide; HDAC Inhibitor VI; AG-2216; AG2216; AG 2216
EINECS	Contact for details

Quality Control

Our Tubacin is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion [M+H]+
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.