Description

-Iodoresiniferatoxin is a potent and selective synthetic analog of resiniferatoxin, specifically engineered for high-affinity binding to the TRPV1 (vanilloid receptor 1) ion channel. This compound matters as a critical pharmacological tool for advanced neuroscience and pain research, enabling precise modulation and study of nociceptive pathways. It is essential for researchers and developers in the pharmaceutical, biotechnology, and academic sectors focused on developing novel analgesics and understanding sensory neuron signaling.

Application

• Neuroscience Research: As a high-affinity TRPV1 agonist/desensitizer for studying pain transduction, neurogenic inflammation, and thermal sensation mechanisms.
• Drug Discovery & Development: A key reference standard and pharmacological probe in screening programs for next-generation non-opioid pain therapeutics.
• Cellular & Molecular Biology: Used to investigate calcium influx, neuronal excitability, and receptor desensitization in transfected cell lines and primary neuronal cultures.
• Preclinical Studies: Employed in animal models to validate targets and assess the efficacy of novel analgesic compounds targeting the vanilloid receptor system.
• Biochemical Assays: Serves as a ligand in receptor binding assays (e.g., competitive displacement studies) to determine affinity constants (Ki) for new chemical entities.

Basic Information

Product Name	-Iodoresiniferatoxin
CAS No.	535974-91-5
Molecular Formula	C40H51NO9I
Molecular Weight	840.75 g/mol
Synonyms	Iodo-resiniferatoxin; I-RTX; (6aR,9R,10S,11aR,11bS)-10-(3-Iodo-4,5-dimethoxyphenyl)-9-(methoxymethyl)-2,3,4,5,6,6a,7,8,9,10,11,11a-dodecahydro-11b-hydroxy-8,8-dimethyl-1H-6,11b-epoxynaphtho[2,1-c]azepine-7-carboxylic acid methyl ester; Iodinated RTX; 5'-Iodo-resiniferatoxin; TRPV1 antagonist I-RTX
EINECS	Contact for details

Quality Control

Our -Iodoresiniferatoxin is produced under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR and MS confirmation of structure, and determination of residual solvents. A detailed Certificate of Analysis (COA) documenting identity, purity, and strength is provided with every shipment to support your regulatory and documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.