Description

Decanoyl-Arg-Val-Arg-Lys-Chloromethylketone is a potent and selective peptide-based chloromethylketone inhibitor, widely recognized for its high specificity in biochemical research. This compound is a critical tool for studying serine protease activity and related signaling pathways, offering researchers a reliable mechanism for targeted enzyme inhibition. It is primarily utilized by pharmaceutical R&D teams, academic biochemistry laboratories, and diagnostic developers focused on protease function and inhibitor design.

Application

• Biochemical Research: A key reagent for the selective inhibition of specific serine proteases in mechanistic and kinetic studies.
• Pharmaceutical Development: Used in early-stage drug discovery to validate protease targets and screen for novel therapeutic candidates.
• Enzymology Studies: Employed to elucidate the role of proteases in complex biological processes and disease models.
• Diagnostic Assay Development: Serves as a control or reference inhibitor in the development of enzymatic activity assays.
• Cell Signaling Pathway Analysis: Used to probe and modulate protease-dependent signaling cascades in cellular systems.

Basic Information

Product Name	Decanoyl-Arg-Val-Arg-Lys-Chloromethylketone
CAS No.	534615-50-4
Molecular Formula	C41H78N14O7Cl
Molecular Weight	898.6 g/mol
Synonyms	Decanoyl-RVKR-CMK; Dec-RVKR-CMK; RVKR Chloromethyl Ketone; Protease Inhibitor RVKR-CMK; Arg-Val-Lys-Arg Chloromethylketone Decanoyl Derivative; (2S)-1-[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-5-[(diaminomethylidene)amino]-2-(decanoylamino)pentanoyl]amino]-3-methylbutanoyl]amino]hexanoyl]-N~2~-[(2S)-5-[(diaminomethylidene)amino]-2-(1-chloro-3-oxopropoxy)pentanoyl]pyrrolidine-2-carboxamide
EINECS	Contact for details

Quality Control

Every batch of Decanoyl-Arg-Val-Arg-Lys-Chloromethylketone is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We ensure high purity and batch-to-batch consistency suitable for sensitive research applications. A detailed Certificate of Analysis (COA) providing purity, identity confirmation, and impurity profile is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.