Description

Caspase-9 Inhibitor CAS NO 524746-03-0 is a potent and selective small molecule inhibitor of caspase-9, a key initiator caspase in the intrinsic apoptosis pathway. This compound is a critical research tool for elucidating the mechanisms of programmed cell death and for screening potential therapeutic agents targeting apoptosis-related diseases. It is primarily utilized by researchers and scientists in the fields of biochemistry, cell biology, and pharmaceutical development.

Application

• Apoptosis Research: Used as a specific inhibitor to study the role of caspase-9 in the mitochondrial apoptotic pathway.
• Drug Discovery Screening: Serves as a reference compound in high-throughput assays to identify novel anti-apoptotic or pro-apoptotic agents.
• Cell Biology Studies: Employed to inhibit caspase-9 activity in cell culture models to understand its function in development, neurodegeneration, and cancer.
• Biochemical Assay Development: Acts as a key component in developing and validating in vitro enzymatic assays for caspase-9 activity.
• Mechanistic Toxicology: Used to investigate the involvement of the intrinsic apoptosis pathway in chemical- or drug-induced cell injury.
• Neuroscience Research: Applied in models of stroke, traumatic brain injury, and neurodegenerative diseases to assess caspase-9's role in neuronal death.

Basic Information

Item	Detail
Product Name	Caspase-9 Inhibitor
CAS No.	524746-03-0
Molecular Formula	C20H16N4O3S
Molecular Weight	392.43 g/mol
Synonyms	Z-LEHD-FMK; Caspase-9 Inhibitor Z-LEHD-FMK; (Benzyloxycarbonyl)-Leu-Glu-His-Asp-fluoromethyl ketone; Z-Leu-Glu-His-Asp-FMK; LEHD-FMK; Caspase 9 Inhibitor; Apoptosis Inhibitor IX; Caspase-9 Selective Inhibitor
EINECS	Contact for details

Quality Control

Our Caspase-9 Inhibitor is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods, to ensure it meets the high standards required for life science research. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.