Description

(4-[4-(Trifluoromethyl)Phenyl]Phenyl)Sulfonylchloride is a high-value aromatic sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in introducing the sulfonyl chloride functional group, a versatile handle for creating sulfonamides and sulfonate esters, which are pivotal in developing active pharmaceutical ingredients and specialty materials. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries seeking to incorporate trifluoromethylphenyl motifs for enhanced bioactivity and physicochemical properties.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides where the sulfonamide linkage and trifluoromethyl group improve efficacy and environmental stability.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for producing high-performance polymers, liquid crystals, and specialty coatings with unique thermal and chemical resistance.
• Chemical Biology & Proteomics: Employed as a reactive probe or labeling reagent for modifying proteins, enzymes, and other biomolecules to study function or create conjugates.
• Dye & Pigment Manufacturing: Intermediate in the production of specialized dyes and pigments where the sulfonyl chloride group enables attachment to various chromophores.
• Custom Synthesis & Contract Manufacturing: Sourced by CROs and CDMOs for client-specific projects requiring bespoke aromatic sulfonation chemistry.

Basic Information

Item	Detail
Product Name	(4-[4-(Trifluoromethyl)Phenyl]Phenyl)Sulfonylchloride
CAS No.	524046-23-9
Molecular Formula	C13H8ClF3O2S
Molecular Weight	320.71 g/mol
Synonyms	4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-sulfonyl chloride; [1,1'-Biphenyl]-4-sulfonyl chloride, 4'-(trifluoromethyl)-; 4-(4-Trifluoromethylphenyl)benzenesulfonyl chloride; p-(p-Trifluoromethylphenyl)benzenesulfonyl chloride; 4'-(Trifluoromethyl)biphenyl-4-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of (4-[4-(Trifluoromethyl)Phenyl]Phenyl)Sulfonylchloride is manufactured and tested under a strict quality management system. We guarantee high purity and consistency to meet the rigorous demands of process chemistry and scale-up. Comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, is performed. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to ensure full traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) in its original packaging to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.