Description

(2S)-1-{n-[2-(5-Methyl-2-Phenyl-1,3-Oxazol-4-Yl)Ethyl]Glycyl}Pyrrolidine-2-Carbonitrile is a high-purity, non-natural amino acid derivative featuring a complex molecular architecture. This compound matters as a sophisticated chiral building block and intermediate, enabling the synthesis of novel peptide-based therapeutics and bioactive molecules. It is primarily needed by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing protease inhibitors, enzyme modulators, and other advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel drug candidates, particularly for targeting specific enzymatic pathways.
• Protease Inhibitor Scaffold: Serves as a core structural component for designing and synthesizing potent inhibitors of proteolytic enzymes.
• Peptidomimetic Chemistry: Used in the construction of peptidomimetics, where its pyrrolidine-2-carbonitrile moiety mimics natural amino acid side chains to enhance metabolic stability and bioavailability.
• Chemical Biology Probe: Employed in the synthesis of specialized probes for studying enzyme function and protein-protein interactions within biological systems.
• Asymmetric Synthesis: Utilized as a chiral auxiliary or precursor in stereoselective synthetic routes to access enantiomerically pure compounds.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke molecules for clinical trials.

Basic Information

Product Name	(2S)-1-{n-[2-(5-Methyl-2-Phenyl-1,3-Oxazol-4-Yl)Ethyl]Glycyl}Pyrrolidine-2-Carbonitrile
CAS No.	521266-46-6
Molecular Formula	C19H22N4O2
Molecular Weight	338.41 g/mol
Synonyms	(2S)-1-[(2-{2-[(5-Methyl-2-phenyl-1,3-oxazol-4-yl)methyl]-1-oxoethyl}amino)ethyl]-2-pyrrolidinecarbonitrile; 1-[(2-{2-[(5-Methyl-2-phenyloxazol-4-yl)methyl]-1-oxoethyl}amino)ethyl]-L-prolinenitrile; L-Proline, 1-[(2-[[2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1-oxoethyl]amino]ethyl]-, nitrile; UNII-5J8I17HL8F; 5J8I17HL8F; (S)-1-((2-((2-((5-Methyl-2-phenyloxazol-4-yl)methyl)-2-oxoethyl)amino)ethyl)carbamoyl)pyrrolidine-2-carbonitrile; Glycine, N-[2-[(5-methyl-2-phenyl-4-oxazolyl)methyl]-1-oxo-2-[[(2S)-2-cyano-1-pyrrolidinyl]carbonyl]ethyl]-
EINECS	Contact for details

Quality Control

Our (2S)-1-{n-[2-(5-Methyl-2-Phenyl-1,3-Oxazol-4-Yl)Ethyl]Glycyl}Pyrrolidine-2-Carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, purity, and related substances are provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.