Description

1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Sulfonyl Chloride is a high-value, reactive sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in enabling the efficient introduction of the sulfonamide functional group, a key motif in modern pharmaceuticals and agrochemicals. This compound is essential for research chemists and process development scientists in the pharmaceutical, crop protection, and specialty chemical industries who require a reliable, high-purity intermediate for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs containing sulfonamide moieties, such as kinase inhibitors and enzyme modulators.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the sulfonamide group contributes to biological activity and selectivity.
• Material Science Research: Employed in the creation of functional polymers and advanced materials, where it can act as a cross-linking agent or a monomer modifier.
• Chemical Biology & Proteomics: Serves as a reactive handle for bioconjugation and the development of chemical probes to study protein function and interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Sulfonyl Chloride
CAS No.	519056-67-8
Molecular Formula	C5H4ClF3N2O2S
Molecular Weight	248.61 g/mol
Synonyms	1-Methyl-3-(trifluoromethyl)-1H-pyrazole-4-sulfonyl chloride; 4-Pyrazolesulfonyl chloride, 1-methyl-3-(trifluoromethyl)-; 1-Methyl-3-trifluoromethyl-1H-pyrazole-4-sulfonyl chloride; 3-Trifluoromethyl-1-methylpyrazole-4-sulfonyl chloride; 1-Methyl-3-(trifluoromethyl)pyrazole-4-sulfonyl chloride; 1-Methyl-3-(trifluoromethyl)-4-pyrazolesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Methyl-3-(Trifluoromethyl)-1H-Pyrazole-4-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.