Description

Chk2 Inhibitor Ii CAS NO 516480-79-8 is a potent and selective small molecule inhibitor of the Checkpoint kinase 2 (Chk2) protein. This compound is a critical research tool for investigating DNA damage response pathways, cell cycle regulation, and apoptosis in various disease models. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in oncology research, drug discovery, and molecular biology studies.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific role of Chk2 kinase in cellular signaling pathways.
• Oncology & Cancer Research: A key tool for exploring DNA damage response mechanisms and their implications in tumorigenesis and cancer cell survival.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the development of novel therapeutic agents targeting Chk2.
• Cell Biology Studies: Employed to investigate cell cycle checkpoints, apoptosis induction, and genomic stability in various cell lines.
• Signal Transduction Analysis: Facilitates the dissection of complex kinase cascades involved in the cellular response to genotoxic stress.

Basic Information

Product Name	Chk2 Inhibitor Ii
CAS No.	516480-79-8
Molecular Formula	C₂₀H₂₀N₄O₃S
Molecular Weight	396.46 g/mol
Synonyms	2-(4-(4-Chlorophenoxy)phenyl)-1H-benzimidazole-5-carboxamide; Chk2 Inhibitor II; BML-277; Checkpoint Kinase 2 Inhibitor II; 2-[4-(4-Chlorophenoxy)phenyl]-1H-1,3-benzodiazole-5-carboxamide; 2-[4-(4-Chlorophenoxy)phenyl]-1H-benzimidazole-5-carboxamide; 2-[4-(4-Chlorophenoxy)phenyl]-5-carbamoylbenzimidazole
EINECS	Contact for details

Quality Control

Our Chk2 Inhibitor Ii is manufactured under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by comprehensive analytical data. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.