Description

Afuresertib CAS NO 515138-06-4 is a potent and selective small-molecule inhibitor of the serine/threonine protein kinase AKT (Protein Kinase B). This compound is of significant interest for its role in targeting the PI3K/AKT/mTOR signaling pathway, a critical regulator of cell growth, proliferation, and survival that is frequently dysregulated in various cancers. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in oncology drug discovery and development.

Application

• Oncology Research: A key investigational tool for studying the role of AKT inhibition in cancer cell proliferation, apoptosis, and tumor growth.
• Preclinical Drug Development: Serves as a lead compound or reference standard in the development of novel anti-cancer therapeutics targeting the PI3K/AKT pathway.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro kinase assays to evaluate AKT selectivity and potency.
• Mechanistic Studies: Facilitates research into drug resistance mechanisms and combination therapy strategies in various cancer models.
• Pharmaceutical Intermediates: Acts as a critical advanced intermediate in the synthesis of targeted cancer therapies.
• Reference Standard: Employed as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical manufacturing.

Basic Information

Product Name	Afuresertib
CAS No.	515138-06-4
Molecular Formula	C₂₃H₂₅ClN₈O₂
Molecular Weight	480.95 g/mol
Synonyms	GSK2110183; Afuresertib (GSK2110183); (S)-5-(2-(1H-Indazol-4-yl)-6-((4-(morpholine-4-carbonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yloxy)indolin-2-one; AKT Inhibitor GSK2110183; GSK 2110183; AZD5363 analog; Protein Kinase B Inhibitor
EINECS	Contact for details

Quality Control

Our Afuresertib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.